top of page



Yamaya K, Wang B, Memar N, Odiba AS, Woglar A, Gartner A, Villeneuve AM. Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells. Nucleic Acids Res. 2023 Sep 22;51(17):9183-9202. doi: 10.1093/nar/gkad638. PMID: 37548405; PMCID: PMC10516670.

Cahoon, C. K., Uebel, C. J., Villeneuve, A.M., Libuda, D. E. Epitope tag-specific differences in the detection of COSA-1 marked crossover sites in C. elegans spermatocytes. microPublication Biology (2023).

Choi, C. P., Villeneuve, A.M. CRISPR/Cas9 mediated genome editing of Caenorhabditis nigoni using the conserved dpy-10 co-conversion marker. microPublication Biology (2023).


Roelens, B. & Villeneuve, A. M. Localization of HIM-19 in the C. elegans germline. MicroPubl Biol 2022 (2022).

Haversat, J., Woglar, A., Klatt, K., Akerib, C. C., Roberts, V., Chen, S. Y., Arur, S., Villeneuve, A. M. & Kim, Y. Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSgamma complex. Proc Natl Acad Sci U S A 119, e2117865119 (2022).

Akerib C.C., Yokoo R., Nsamba E.T., Strand L.G., Yamaya K., Villeneuve A.M. A new partial loss of function allele of rad-54.L. microPublication Biology (2022).


Girard, C., Akerib, C. C. & Villeneuve, A. M. Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1. MicroPubl Biol 2021 (2021).

Hinman, A. W., Yeh, H. Y., Roelens, B., Yamaya, K., Woglar, A., Bourbon, H. G., Chi, P. & Villeneuve, A. M. Caenorhabditis elegans DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaks. Proc Natl Acad Sci U S A 118 (2021).


Woglar, A., Yamaya, K., Roelens, B., Boettiger, A., Kohler, S. & Villeneuve, A. M. Quantitative cytogenetics reveals molecular stoichiometry and longitudinal organization of meiotic chromosome axes and loops. PLoS Biol 18, e3000817 (2020).


Roelens, B., Barroso, C., Montoya, A., Cutillas, P., Zhang, W., Woglar, A., Girard, C., Martinez-Perez, E. & Villeneuve, A. M. Spatial Regulation of Polo-Like Kinase Activity During Caenorhabditis elegans Meiosis by the Nucleoplasmic HAL-2/HAL-3 Complex. Genetics 213, 79-96 (2019).

Roelens, B., Zawadzki, K. & Villeneuve, A. me98 is a new allele of rad-54. MicroPubl Biol 2019 (2019).

Roelens, B., Zawadzki, K. & Villeneuve, A. me101 is a new allele of rad-51. MicroPubl Biol 2019 (2019).


Girard, C., Roelens, B., Zawadzki, K. A. & Villeneuve, A. M. Interdependent and separable functions of Caenorhabditis elegans MRN-C complex members couple formation and repair of meiotic DSBs. Proc Natl Acad Sci U S A 115, E4443-E4452 (2018).

Woglar, A. & Villeneuve, A. M. Dynamic Architecture of DNA Repair Complexes and the Synaptonemal Complex at Sites of Meiotic Recombination. Cell 173, 1678-1691 e1616 (2018).


Mlynarczyk-Evans, S. & Villeneuve, A. M. Time-Course Analysis of Early Meiotic Prophase Events Informs Mechanisms of Homolog Pairing and Synapsis in Caenorhabditis elegans. Genetics 207, 103-114 (2017).

Pattabiraman, D., Roelens, B., Woglar, A. & Villeneuve, A. M. Meiotic recombination modulates the structure and dynamics of the synaptonemal complex during C. elegans meiosis. PLoS Genet 13, e1006670 (2017).


Gabdank, I., Ramakrishnan, S., Villeneuve, A. M. & Fire, A. Z. A streamlined tethered chromosome conformation capture protocol. BMC Genomics 17, 274 (2016).

Jagut, M., Hamminger, P., Woglar, A., Millonigg, S., Paulin, L., Mikl, M., Dello Stritto, M. R., Tang, L., Habacher, C., Tam, A., Gallach, M., von Haeseler, A., Villeneuve, A. M. & Jantsch, V. Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance. PLoS Biol 14, e1002412 (2016).

Wolff, I. D., Tran, M. V., Mullen, T. J., Villeneuve, A. M. & Wignall, S. M. Assembly of Caenorhabditis elegans acentrosomal spindles occurs without evident microtubule-organizing centers and requires microtubule sorting by KLP-18/kinesin-12 and MESP-1. Mol Biol Cell 27, 3122-3131 (2016).


Roelens, B., Schvarzstein, M. & Villeneuve, A. M. Manipulation of Karyotype in Caenorhabditis elegans Reveals Multiple Inputs Driving Pairwise Chromosome Synapsis During Meiosis. Genetics 201, 1363-1379 (2015).


Holloway, J. K., Sun, X., Yokoo, R., Villeneuve, A. M. & Cohen, P. E. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J Cell Biol 205, 633-641 (2014).

Schvarzstein, M., Pattabiraman, D., Libuda, D. E., Ramadugu, A., Tam, A., Martinez-Perez, E., Roelens, B., Zawadzki, K. A., Yokoo, R., Rosu, S., Severson, A. F., Meyer, B. J., Nabeshima, K. & Villeneuve, A. M. DNA helicase HIM-6/BLM both promotes MutSgamma-dependent crossovers and antagonizes MutSgamma-independent interhomolog associations during Caenorhabditis elegans meiosis. Genetics 198, 193-207 (2014).


Bilgir, C., Dombecki, C. R., Chen, P. F., Villeneuve, A. M. & Nabeshima, K. Assembly of the Synaptonemal Complex Is a Highly Temperature-Sensitive Process That Is Supported by PGL-1 During Caenorhabditis elegans Meiosis. G3 (Bethesda) 3, 585-595 (2013).

Labrador, L., Barroso, C., Lightfoot, J., Muller-Reichert, T., Flibotte, S., Taylor, J., Moerman, D. G., Villeneuve, A. M. & Martinez-Perez, E. Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis. PLoS Genet 9, e1003497 (2013).

Libuda, D. E., Uzawa, S., Meyer, B. J. & Villeneuve, A. M. Meiotic chromosome structures constrain and respond to designation of crossover sites. Nature 502, 703-706 (2013).

Mlynarczyk-Evans, S., Roelens, B. & Villeneuve, A. M. Evidence that masking of synapsis imperfections counterbalances quality control to promote efficient meiosis. PLoS Genet 9, e1003963 (2013).

Rosu, S., Zawadzki, K. A., Stamper, E. L., Libuda, D. E., Reese, A. L., Dernburg, A. F. & Villeneuve, A. M. The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance. PLoS Genet 9, e1003674 (2013).

Schvarzstein, M., Pattabiraman, D., Bembenek, J. N. & Villeneuve, A. M. Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis. Proc Natl Acad Sci U S A 110, E898-907 (2013).

Stamper, E. L., Rodenbusch, S. E., Rosu, S., Ahringer, J., Villeneuve, A. M. & Dernburg, A. F. Identification of DSB-1, a protein required for initiation of meiotic recombination in Caenorhabditis elegans, illuminates a crossover assurance checkpoint. PLoS Genet 9, e1003679 (2013).


Voelkel-Meiman, K., Moustafa, S. S., Lefrancois, P., Villeneuve, A. M. & MacQueen, A. J. Full-length synaptonemal complex grows continuously during meiotic prophase in budding yeast. PLoS Genet 8, e1002993 (2012).

Yokoo, R., Zawadzki, K. A., Nabeshima, K., Drake, M., Arur, S. & Villeneuve, A. M. COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers. Cell 149, 75-87 (2012).

Zhang, W., Miley, N., Zastrow, M. S., MacQueen, A. J., Sato, A., Nabeshima, K., Martinez-Perez, E., Mlynarczyk-Evans, S., Carlton, P. M. & Villeneuve, A. M. HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors. PLoS Genet 8, e1002880 (2012).

bottom of page